Inohara T, et al. - Using data from the admissions in the Get With The Guidelines-Stroke hospitals, researchers investigated whether treatment with recombinant tissue-type plasminogen activator (rtPA) is safe in patients with acute ischemic stroke (AIS) with a history of recent myocardial infarction (MI). They investigated the impact of recent MI on the risk of mortality and rtPA-related complications. They compared rtPA-treated AIS patients with recent MI within 3 months to those with no history of MI, in terms of in-hospital outcomes, using multivariate logistic regression models. More severe stroke was reported in patients with recent MI vs those without. The rtPA-related complications did not show a statistically significant difference between the groups. An increased risk of in-hospital mortality was reported in relation to recent MI in older AIS patients treated with rtPA.