Azzalini L, et al. - Researchers evaluated the outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in patients with vs without chronic kidney disease (CKD) in a multicenter registry. They also determined the effect of contrast-induced acute kidney injury (CI-AKI). Follow-up was focused on CI-AKI and all-cause death and target-lesion failure (TLF: cardiac death, target-vessel myocardial infarction, or target-lesion revascularization). They reported lower success rates and higher incidence of CI-AKI in relation to CTO PCI in CKD patients. Dialysis was infrequently required both in-hospital and on follow-up. Higher rates of all-cause death were reported in CKD patients, but TLF rates were found to be similar regardless of CKD status.