Tan VY, et al. - Using summary statistics from the PRACTICAL consortium (44,825 cases; 27,904 controls), researchers performed a Mendelian randomization analyses (MR) to reassess connections between insulin-like growth factor binding protein 3 (IGFBP-3) and prostate cancer (PCa) risk and advanced PCa. According to the findings, IGFBP-3 was a risk factor for PCa risk and progression. It was noted that 25(OH)D was associated with IGFBP-3, but MR analyses inferred that these findings were unlikely to be causal. Data revealed that 25(OH)D seems unlikely to be causally associated with IGFBP-3 in the circulation, but findings do not disqualify causal associations at the tissue level.