Seymour EK, et al. - Researchers conducted the National Cancer Institute-sponsored Patterns of Care study to assess the changes in patterns of real-world testing and treatment for chronic lymphocytic leukemia (CLL) by comparing two population-based cohorts. A total of 1,008 patients diagnosed in 2008 and 1,367 patients diagnosed in 2014 were identified from 14 Surveillance, Epidemiology, and End Results (SEER) program registries. Observations suggest that between 2008 and 2014, a marked increase in fluorescence in situ hybridization (FISH) testing, immunoglobulin heavy-chain variable region gene (IgV_H) mutation analyses, and lymph node biopsies. Different testing patterns were noted by practice type and year, with nonteaching hospitals more frequently performing bone marrow biopsies in 2008, and teaching hospitals more frequently performing FISH and IgV_H testing in 2014. Treatments also differed over time, with more common use of bendamustine and rituximab in 2014, at the expense of fludarabine, cyclophosphamide, and rituximab.