Real-world experience of everolimus as second-line treatment in metastatic renal cell cancer after failure of pazopanib
OncoTargets and Therapy Oct 16, 2017
Koutsoukos K, et al. - In this study, real-life data was presented on the outcomes of metastatic renal cell carcinoma (mRCC) patients treated with everolimus as second-line treatment after failure of first-line pazopanib. Everolimus proved to have a favorable safety profile and was active in these patients. The pazopanibÂeverolimus sequence was mainly offered to patients with adverse prognostic features that seemed to attribute to the short progression-free survival and overall survival, thereby resulting in a modest increase in the combined overall survival (OS) of the population.
Methods
- Researchers reviewed data from the medical charts of mRCC patients from 8 centers in Greece and Spain.
- Second-line everolimus treatment was administered or was continued in all patients after failure of first-line treatment with pazopanib.
- They allowed no other previous therapies.
- The determination of progression-free survival (PFS) was observed as the primary end point.
Results
- This study included 31 patients.
- Of these, 26% indicated performance status (PS) >0, 88% were of intermediate/poor Memorial Sloan-Kettering Cancer Center (MSKCC) risk group, and only 61% had undergone prior nephrectomy.
- Median PFS of 3.48 months (95% CI: 2.37Â5.06 months) was observed.
- Observations revealed median overall survival (OS) of 8.9 months (95% CI: 6.47Â13.14 months) from everolimus initiation.
- From pazopanib initiation, median OS was 14.78 months (95% CI: 10.54Â19.08 months).
- Due to adverse events (AEs), 32% of patients temporarily discontinued everolimus.
- Due to toxicity, 22% of patients discontinued everolimus permanently.
- In this study, the most common toxicities included anemia (29%), stomatitis (26%), pneumonitis (19%), and fatigue (10%).
- Moreover, 13 patients (42%) reported 14 AEs (27%) that were graded as 3 or 4.
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