Dathan-Stumpf A, Czarnowsky V, Hein V, et al. - In this real-world data analysis, researchers sought to examine the utility of soluble fms-like tyrosine kinase-1 and placental growth factor for preeclampsia and placental dysfunction. Using Elecsys soluble fms-like tyrosine kinase-1 and placental growth factor immunoassays (cobas e analyzer; Roche Diagnostics), blood serum soluble fms-like tyrosine kinase-1 and placental growth factor were measured. A total of 283 unselected singleton pregnancies with ≥ 1 determination of soluble fms-like tyrosine kinase-1–to–placental growth factor ratio were involved. A positive association was found between soluble fms-like tyrosine kinase-1–to–placental growth factor ratio and severity of placental dysfunction and a negative association with time to delivery, confirming the findings of prospective studies. In the real world, the soluble fms-like tyrosine kinase-1–placental growth factor ratio differentiates between patients with normal outcomes and those with outcomes complicated by placental dysfunction.