Varobieff M, Choquet O, Swisser F, et al. - Given that integrating nerve stimulation and injection pressure (IP) monitoring with ultrasound guidance has been advised to optimize needle tip location in peripheral nerve block (PNB), researchers investigated in this prospective observational study if measured pairs of IP and minimum intensity of stimulation (MIS) might distinguish successive needle tip locations established by high-resolution ultrasound during PNB. This analysis involved 28 patients scheduled for orthopedic surgery. Overall 240 observations for 40 ultrasound-guided PNBs were analyzed in these patients. For subcutaneous, epimysium contact, intramuscular, nerve contact, intraneural location, and subparaneural location, specific combinations of IP and MIS were measured. In this exploratory study, experts assessed concepts to produce hypotheses. They inferred that the physician might be helped by the combinations of IP and MIS during a PNB procedure. A subparaneural location might be confirmed by a low IP and low MIS, and a high IP and a low MIS might work as an alert for the intraneural location of the needle tip.