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Readmissions, death and its associated predictors in heart failure with preserved vs reduced ejection fraction

Journal of the American Heart Association Oct 27, 2021

Tay WT, Teng THK, Simon O, et al. - Asian patients with heart failure (HF) were found to have high 1‐year HF rehospitalization and mortality rates. This study unveils predictors of outcomes which could help in risk stratification and timely interventions.

  • In the multinational ASIAN‐HF (Asian Sudden Cardiac Death in Heart Failure) registry, patients with HF and preserved (n=1,666) or reduced (n=4,479) ejection fraction [EF] were compared for burden and predictors of HF (first and recurrent) rehospitalizations and all‐cause death.

  • In HF with preserved EF vs reduced EF, the 1‐year composite event rate for first HF hospitalization or all‐cause death was 11% vs 21%, for total HF hospitalization and all‐cause death was 17.7 vs 38.7 per 100 patient‐years, respectively.

  • This shows higher overall event rates in HF with reduced EF vs HF with preserved EF.

  • In both HF phenotypes, the consistent independent predictors of these clinical endpoints were: enrollment as an inpatient, Southeast Asian location, and comorbid chronic kidney disease.

  • Northeast Asian location, older age, increased heart rate, reduced systolic blood pressure, diabetes, smoking and non‐usage of beta‐blockers were also predictive of outcomes in HF with reduced EF.

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