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Reactive granulomatous dermatitis as a histologic pattern including manifestations of interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: A study of 52 patients

Journal of the European Academy of Dermatology and Venereology Oct 28, 2020

Rodríguez‐Garijo N, Bielsa I, Mascaró JM, et al. - This observational retrospective multicenter study was undertaken to determine if interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic and granulomatous dermatitis (PNGD) are two different entities, or if they must be considered as two subtypes of the same reactive pattern, and thus if the unification of the nomenclature is necessary. The sample consisted of patients with IGD and PNGD assessed between 1999 and 2019 and a review of their clinical and histological characteristics. Fifty-two patients (38 women and 14 men) were identified. Plaques/macules (IGD) or annular plaques and papules/nodules (PNGD), located mostly on the limbs and trunk were the most common cutaneous lesions. PNGD biopsies were mainly associated with neutrophilic infiltrates, karyorrhexis and skin lesions with limited clinical course. The authors support the term reactive granulomatous dermatitis to unify both the clinical and histological results of IGD and PNGD, and the overlapping between IGD and interstitial granuloma annulare. According to this, depending on the clinical course of the skin lesions, a spectrum of histological changes can be observed.

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