Higashioka M, Hirakawa Y, Kawamura R, et al. - In the general population, researchers explored the connection between the ratio of serum levels of n−3 to serum n−6 polyunsaturated fatty acids (PUFAs) and the serum resistin [an adipocyte-derived polypeptide that results in insulin resistance progression and subsequent atherosclerosis] concentration. The study sample consisted of 3,200 community-dwelling Japanese individuals aged ≥ 40 years in 2002–2003. Using linear regression models with adjustment for potential confounding factors, the connections of serum eicosapentaenoic acid/AA and docosahexaenoic acid/AA with the serum resistin concentration were evaluated. Data reported that the geometric mean of serum resistin was 10.3 ng/mL. With increased levels of serum eicosapentaenoic acid/AA, the age- and sex-adjusted geometric mean of serum resistin decreased significantly. A comparable association for docosahexaenoic acid/AA serum has been noted. These associations were not changed by an adjustment for potential confounding factors. Lower serum resistin levels were associated with higher serum ratios n−3 to n−6 PUFAs. Consumption of a large amount of n−3 PUFAs may have desirable effects on diseases caused by resistin.