Ali M, et al. - Via this retrospective, longitudinal (cohort) study including 100 patients in the Intensive care unit (ICU) of the largest tertiary care hospital of the capital city of Pakistan, researchers assessed the rational use of antibiotic therapy in ICU patients. Further, they determined how it impacts the clinical outcomes and mortality rate. Findings revealed that in 68% of patients, empiric antibiotic therapy was initiated, while only 19% of patients underwent a culture sensitivity test. Empiric antibiotic therapy was identified as beneficial in patients and results in a reduction in the mortality rate. They observed high mortality rate and poor clinical outcomes in correlation with factors such as irrational antibiotic selection, prescribing contraindicated drug combinations, and use of nephrotoxic drugs.