Mahmoudinezhad G, Lin M, Rabiolo A, et al. - This study was attempted to assess whether and how the presence of an acquired pit of the optic nerve (APON) is associated with the rate of visual field (VF) decay in primary open-angle glaucoma (POAG). Researchers screened consecutive patients with POAG for APON by three glaucoma specialists. Comparison was made between a control group of POAG eyes without APON and the APON group for factors such as age, gender, baseline intraocular pressure and baseline mean deviation (MD). They applied pointwise rate of change for pointwise comparisons between the two groups. They further applied MD rate, Visual Field Index (VFI) rate and Glaucoma Rate Index (GRI) for global rate comparisons. The proportions of eyes progressing in the groups compared with event-based guided progression analysis, MD, VFI and GRI criteria. The data reveal that presence of APON in patients with POAG is correlated with focal, fast rates of VF decay. The results recognize that identification of patients with APON should alert clinicians to the possibility of a fast rate of functional progression and to consider appropriately aggressive treatment of their glaucoma.