Veras AB, et al. - This study was performed to examine whether rare missense coding variants in oxytocin receptor (OXTR) in schizophrenia cases were correlated with early trauma exposure, cognition, and emotional processing. Less negative and affective symptoms were noticed in cases carrying rare OTXR single nucleotide variants (SNVs) than other cases, but similar psychotic symptoms, along with specific cognitive deficits. The clinical characterization of these cases occurred in association with environmental exposure to early trauma, particularly sexual abuse, which could have influenced the expression of schizophrenia in subjects harboring specific SNVs in the OXTR.