Urick B, et al. - Researchers here aimed to understand the performance of rapid serological tests in high HIV burden, high Option B+ coverage settings to be used as an HIV exposure screening tool. Among infants presenting at both well-child (immunization and community outreach) and sick-infant (nutrition and inpatient) entry points, the use of rapid serological tests could have inadequate performance as an indicator of exposure and potential HIV infection. Instead, they recommended considering nucleic acid–based testing in infants aged younger than 18 months to improve the identification of HIV-positive infants.