Jin GH, et al. - Authors assessed the role of RAP80 (a member of BRCA1-A complex) expression in the biological response of breast cancer cells. They observed a lower RAP80 expression in breast cancer, especially triple-negative breast cancer, vs adjacent normal breast tissues. They noted a relation of RAP80 mRNA expression to tumor size, lymph node metastasis, TNM stage, and molecular subtype. They reported induction of apoptosis in breast cancer cells and improved chemosensitivity to cisplatin when RAP80 expression was inhibited. They also suggested that tumor cells could activate the protective responses to repress cell cycle progression (might be related to RAP80) and restore cisplatin-induced DNA damage.