Sue S, et al. - In this prospective, randomized trial, researchers tested the effectiveness of vonoprazan-based and proton-pump-inhibitor-based 7-day triple regimens with amoxicillin and sitafloxacin as a third-line therapy for eradicating Helicobacter pylori after the failure of clarithromycin- and metronidazole-based first- and second-line therapy by analyzing data of 63 patients positive for Helicobacter pylori in whom first- and second-line regimens for eradicating failed. For eradicating Helicobacter pylori, 7-day triple therapy with vonoprazan, amoxicillin, and sitafloxacin was more effective than proton-pump-inhibitor, amoxicillin, and sitafloxacin as a third-line regimen.