Sakihara T, Otsuji K, Arakaki Y, et al. - Researchers conducted this randomized controlled trial to ascertain if the early introduction of cow’s milk formula (CMF) could serve as an effective strategy in the primary prevention of cow’s milk allergy (CMA) in a general population. Newborns were recruited from 4 hospitals in Okinawa, Japan. Study participants were assigned randomly to ingest ≥ 10 mL of CMF daily (ingestion group) or avoid CMF (avoidance group) between 1 and 2 months of age. Five hundred four infants were identified for randomization into the 2 groups. Twelve participants refused to undergo the intervention, and 491 participants (ingestion group: 242; avoidance group: 249) engaged in the study sample for a modified intention-to-treat analysis. Nearly 70% of participants in both groups received breastfeeding at 6 months of age. Regular intake of CMF between the ages of 1 and 2 months precludes the development of CMA. This approach does not compete with breastfeeding.