Sun X, et al. – Markers of brain injury were compared in patients receiving moderate or deep hypothermia anesthesia for Stanford A aortic dissection surgery. In both groups, no significant differences were noted with respect to hospital stay and death rate. Moderate hypothermia (MH) group versus deep hypothermia (DH) group showed better cerebral protective effects, less complications, and shorter tube time.

Methods

• In this study, researchers randomized a total of 82 patients who would undergo Stanford A aortic dissection surgery, into two groups: moderate hypothermia group (MH, n = 40, nasopharyngeal temperature 25 °C, and rectal temperature 28 °C) and deep hypothermia group (DH,n = 42, nasopharyngeal temperature 20 °C, and rectal temperature 25 °C).
• They used different vascular replacement techniques including aortic root replacement, Bentall, and Wheat.
• They recorded the intraoperative and postoperative indicators of these patients.

Results

• Findings demonstrated no differences in intraoperative and postoperative measures between MH and DH groups.
• Researchers observed that the concentrations of neuron-specific enolase and S-100β increased with operation time, and were significantly lower in MH group than those in the DH group (P < 0.05).
• They also noted that the occurrence rates of complications including chenosis, postoperative agitation, and neurological complications in MH group were significantly lower than in DH group.
• Data revealed that the recovery time, postoperative tube, and ICU intubation stay were significantly shorter in MH group than those in DH group (P < 0.05).
• In addition, no significant differences were evident in hospital stay and death rate.