Medeiros M, et al. – The effect of long–term eplerenone administration on renal allograft function in children with biopsy–proven chronic allograft nephropathy (CAN) was examined in the translational study. Findings of this study encouraged testing the potential benefit of mineralocorticoid receptor blockade (MRB) in this pediatric population. However, this study found to be underpowered to provide definitive evidence that long–term eplerenone administration attenuated the progression of CAN in pediatric transplant patients.