Irish AK, et al. – This pilot study aimed to assess a modified Paleolithic dietary intervention (MPDI) in the treatment of fatigue and other symptoms in relapsing–remitting multiple sclerosis (RRMS). By reducing perceived fatigue, increasing the mental and physical quality of life, increasing exercise capacity, and improving hand and leg function, a Paleolithic diet could be useful in the treatment and management of multiple sclerosis (MS). The MPDI could also reduce inflammation by increasing vitamin K serum levels.

• In 17 individuals with RRMS, the effects of a MPDI were measured.
• 9 subjects (one man) completed the control group and 8 subjects (one man) completed the MPDI out of 34 subjects randomly assigned to control (maintain usual diet) and intervention (MPDI) groups.

• The researchers observed significant improvements in Fatigue Severity Scale score and also in Multiple Sclerosis Quality of Life-54 and time to complete (dominant hand) 9-Hole Peg Test from baseline in MPDI subjects compared to controls.
• In MPDI subjects postprotocol, increased vitamin K serum levels were also observed compared to controls.