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Randomised double-blind comparison of bolus phenylephrine or ephedrine for treatment of hypotension in women with pre-eclampsia undergoing caesarean section

Anaesthesia Jun 16, 2018

Mohta M, et al. - Researchers compared phenylephrine to ephedrine as treatment options for hypotension in pre-eclamptic women with a singleton pregnancy who underwent caesarean section with spinal anaesthesia, and who developed hypotension defined as a decrease in systolic arterial pressure ≥ 20% from baseline or absolute value < 100 mmHg. They found similar fetal acid-base values resulting from administration of phenylephrine 50μg and ephedrine 4 mg as intravenous boluses to treat post-spinal hypotension during caesarean section in pre-eclamptic patients. Moreover, both of these treatment options showed equal efficacy in treating hypotension and were associated with good maternal and neonatal outcome.
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