Morasso CF, Sproviero D, Mimmi MC, et al. - Researchers examined by Raman spectroscopy small extracellular vesicles (sEVs), large extracellular vesicles (lEVs), and blood plasma of sporadic Amyotrophic lateral sclerosis (ALS) patients and of a matched cohort of healthy controls. The outcomes of this research indicated lEVs as a particularly promising biomarker for ALS. In fact, their Raman spectra display that sporadic ALS individuals have different lipid content and less intense bands relative to the aromatic amino acid phenylalanine.