Qureishi Ali, Rieunier G, Shah KA, et al. - In this investigation, researchers evaluated type 1 insulin-like growth factor receptor (IGF-1R) as a predictor of radioresistance in laryngeal squamous cell carcinoma (LSCC), and examined whether IGF blockade alone or with epidermal growth factor receptor (EGFR) inhibition enhances radiosensitivity in an induced radioresistance model. IGF-1R and EGFR immunohistochemical scores were compared in patients with LSCC achieving long-term remission postradiotherapy (n = 23), patients treated with primary laryngectomy (n = 22) or salvage laryngectomy following radiotherapy recurrence (n = 18). In pretreatment biopsies of radiotherapy failures, the expression of IGF-1R was greater than in long-term remission and postradiotherapy was upregulated. Compared with patients achieving long-term remission, those with primary laryngectomy had more advanced T/N stage and greater tumour IGF-1R content. Pretreatment EGFR was not linked to radiotherapy results but showed a trend towards postirradiation upregulation. Radiation upregulates IGF-1R and may enhance dependence on IGF/EGFR, implying that IGF/EGFR blockade may have recurring postradiotherapy activity in LSCCs.