Ryska P, et al. - In this study including 35 people with clinically confirmed idiopathic normal pressure hydrocephalus (iNPH) and 45 matched healthy controls (HC), researchers compared 15 cross-sectional imaging iNPH biomarkers with regard to their diagnostic performance. Two independent readers collected values of linear, angular and index measurements including three newly proposed biomarkers, via 3T brain MRI studies. They used receiver operating characteristic analysis and t-statistic to analyze the diagnostic performance of biomarkers. Reliable discrimination of iNPH individuals from HC was enabled by all biomarkers examined except for cella media-to-temporal horn ratio. Among 15 radiological iNPH biomarkers examined, the best diagnostic performance was provided by linear measurements referring to caudocranial changes of the ventricular geometry, outweighing those referring to laterolateral ventricular enlargement (as eg, commonly used Evans index). Findings revealed that the outcomes demonstrated by simple linear measurements of vertical or horizontal frontal horn diameters were comparable to calculated, more time-consuming z-Evans or Evans indexes, respectively.