James DL, Ryan EJ, Davey MG, et al. - The selection of the studies was carried out using PubMed, Cochrane Collaboration, Embase, Scopus, and Web of Science to assess the long-term cure rate of different radioactive iodine (RAI) activities in low- and intermediate-risk differentiated thyroid cancer (DTC). The primary outcome was disease recurrence, while secondary outcomes included successful ablation, adverse effects, and length of stay. Participants in the study were 3,821 patients. Low-activity RAI was comparable to high-activity RAI in terms of successful ablation and recurrence rates in this systematic review and meta-analysis. This suggests that in low- and intermediate-risk DTC, low-activity RAI is preferable to high-activity RAI due to similar efficacy but lower morbidity.