Li N, et al. - In this retrospective analysis of patients who underwent total knee arthroplasty (TKA) from 2008 to 2018, researchers investigated when soft-tissue gas was no longer an expected postoperative radiographic finding, and if early prosthetic joint infection (PJI) could be predicted by soft-tissue gas. They also inquired if there existed a correlation between the presence of soft-tissue gas and specific patient features and microbiology culture findings. In 13 of 24 (54.2%) cases with early PJI and four of 180 (2.2%) cases without PJI, radiography performed after surgery revealed the presence of soft-tissue gas. Findings revealed the predictive ability of postoperative soft-tissue gas present on radiography performed 14 days or more post-TKA for early PJI, as well as its link with a wider spectrum of microorganisms.