Rapp CT, et al. - Via analyzing 159 individuals treated curatively between 1963 and 2016, researchers reported their institution's experience treating soft palate squamous cell carcinoma with radiotherapy alone or combined with adjuvant chemotherapy and/or neck dissection for residual disease. There were 4 years of median follow-up. Data reported that the 5-year local control rates were T1, 90%; T2, 90%; T3, 70%; and T4, 59%. Compared with stage IVA/B, the 5-year cause-specific survival (CSS) rate was almost identical for patients with stage I-III disease. Five-year overall survival was comparable between patients with stage I-III disease and nearly double that of patients with stage IVA/B disease. Data reported that 13 patients had serious radiotherapy-related complications. In patients with stage I-III disease with soft palate carcinoma, the possibility of cure after definitive radiotherapy was relatively high. Stage IVA/B disease patients had a lower cure rate but with a 5-year CSS exceeding 50%.