Kabarriti R, et al. - Researchers evaluated the correlation between radiation therapy (RT) use and overall survival (OS) for patients with metastatic head and neck squamous cell carcinomas (HNSCC). They collected and analyzed data from the National Cancer Database to identify patients with newly diagnosed metastatic HNSCC (2004-2013) who were treated with up-front chemotherapy. They noted an association of the addition of RT to chemotherapy in the up-front management of metastatic HNSCC with prolonged OS. Upon propensity score-matching and landmark analyses limited to patients who survived at least 3, 6, and 12 months after diagnosis, the use of RT remained associated with prolonged survival after adjusting for other prognostic factors in a multivariable Cox model.