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Radiation dose to the masseter and medial pterygoid muscle in relation to trismus after chemoradiotherapy for advanced head and neck cancer

Head & Neck Apr 21, 2019

Kraaijenga SA, et al. - Data were researched to examine the association between trismus (maximum interincisor opening [MIO] ≤35 mm) and the dose to the ipsilateral masseter muscle (iMM) and ipsilateral medial pterygoid muscle (iMPM) after chemoradiotherapy for advanced head and neck cancer. Due to proximity, dose levels of iMM and iMPM were highly correlated. They found that both iMPM and iMM dose parameters were predictive for trismus, mainly mean dose and intermediate dose-volume parameters. They noted that adding bMIO significantly improved Normal Tissue Complication Probability models. They suggested optimal cutoffs, 58 Gy (mean dose iMPM), 22 Gy (mean dose iMM) and 46 mm (bMIO).
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