Guedeney P, Thiele H, Kerneis M, et al. - Researchers performed this post hoc analysis of the CULPRIT-SHOCK trial to gain clarity regarding the use as well as effect of transradial artery access (TRA) vs transfemoral artery access (TFA) in patients receiving percutaneous coronary intervention (PCI) for acute myocardial infarction (MI) complicated by cardiogenic shock (CS). Patients presenting with MI and multivessel disease complicated by CS were randomly assigned to a strategy of culprit-lesion-only or immediate multivessel PCI. The composite of mortality or renal replacement therapy (RRT) at 30 days and 1 year were evaluated. Experts reported a lower 30-day rate of death or RRT, a lower 30-day rate of death, and a lower 30-day rate of RRT, all in relation to TRA vs TFA. The noted decrease of death or RRT and death with TRA was no longer significant at 1 year. Overall, improved early outcomes may be achieved with TRA in patients undergoing PCI for acute MI complicated by CS.