Chiarito M, Cao D, Nicolas J, et al. - Whether benefits related to radial vs femoral access for coronary angiography and percutaneous coronary interventions (PCI) are because of the access site selection itself, operator expertise or other underlying mechanisms, was investigated herein. Randomized trials that compared radial vs femoral access site for coronary angiography and PCI were identified from PubMed, Embase, and meeting abstracts. A total of 31 trials (30,096 patients, PCI done in 21,225 patients) were identified. In this systematic review and meta‐analysis, a significant risk reduction in bleeding, vascular complications, and mortality was reported in relation to radial access vs femoral access in patients receiving coronary angiography and PCI. Comparable risks of stroke or myocardial infarction were present in patients with radial or femoral access.