O'Muircheartaigh J, et al. - Among 56 patients with relapsing–remitting multiple sclerosis (MS) and 38 healthy controls, researchers compared four established myelin-sensitive magnetic resonance imaging (MRI) techniques: Multi-echo T₂ relaxation, mcDESPOT (multi-component driven equilibrium single pulse observation of T₁ and T₂), magnetization-transfer ratio (MTR), and quantitative T₁ (qT₁). Variations between MS normal-appearing white matter (WM) and healthy control WM were demonstrated by all measures in eight WM tracts, with qT₁ displaying the highest number of different regions (8), followed by MWF-D (the fraction of signal attributed to myelin water from mcDESPOT) and MTR (6), and MWF-G (n = 4; MWF measurement obtained using a GRadient And Spin Echo). The best accuracy was shown by MWF-D when the methods were compared with respect to their statistical sensitivity to MS lesions in WM. In this study, the average and standard deviation volumes of the four techniques, calculated from the healthy controls, is offered for future power analysis.