Stein D, et al. - Researchers examined the ability of apparent diffusion coefficient (ADC) heterogeneity index to discriminate liver metastases (LM) from normal-appearing liver (NAL) tissue as compared to common magnetic resonance imaging (MRI) metrics, as well as investigated its relationship with 2-[¹⁸F]-fluoro-2-deoxy-d-glucose (¹⁸F-FDG) positron-emission tomography (PET) standardised uptake value (SUV). For the purpose of this investigation, thirty-nine liver metastases in 24 oncology patients with proven LM from heterogeneous sources were evaluated on a PET/MRI system. Results of this study suggested that the ADCcv index was a potential biomarker of LM with better correlation to ¹⁸F-FDG PET SUVpeak than conventional MRI metrics, and could serve to quantitatively discriminate between LM and NAL.