Aleman TS, et al. - Researchers aimed at determining the microstructural changes of the retina in congenital Zika syndrome (CZS) and compare these changes with those of cobalamin C (cblC) deficiency, a disease with potential retinal maldevelopment. In this study, congenital Zika syndrome was characterized by a central retinal degeneration with severe ganglion cell layer (GCL) loss, borderline inner nuclear layer thinning, and less prominent photoreceptor loss. The findings presented the first in vivo evidence in humans for possible retinal maldevelopment with a predilection for retinal GCL loss in CZS, consistent with an experimental model of the disease and suggestive of in utero depletion of this neuronal population as a consequence of Zika virus infection.