Fernandes CD, et al. - Through a prospective case-control study of 33 patients with biochemical failure after external-beam radiotherapy (cases), 35 patients without the post-radiotherapy recurrent disease (controls), and 13 patients with primary prostate cancer (untreated), the researchers intended to quantitatively identify radio-recurrent tumor and benign radiation-induced changes using multiparametric MRI (mp-MRI), and investigate which sequences would optimize the differentiation between tumor and benign surroundings. All imaging maps could distinguish recurrent tumor from the benign peripheral zone, but only ADC, K^trans, and k^ep could demarcate it from a benign central gland. In contrast to recurrent tumor and peri-urethral K^trans values, k^ep were significantly different. Hence, it was concluded that p-MRI could separate recurrent tumor from benign tissue.