Bier G, et al. - Researchers evaluated and quantified the prevalence and co-occurence of a sellar floor lowering and empty sella phenomenon in patients with GH (growth hormone)-secreting pituitary adenoma. This study was conducted on one hundred fifty-nine acromegalic patients as well as two control groups (150 patients with non-GH-secreting adenomas and 50 patients without pituitary adenomas). They reported that GH-secreting pituitary adenomas were frequently related to an empty sella phenomenon. They also discovered that GH-secreting adenomas were frequently accompanied by an enhanced, quantitatively measurable impression of the sellar floor. Hypothetically, this was caused by tumor-induced local bone remodeling processes.