Schaller A, et al. – In this current study, the physicians explored the potential factors that might influence the quality of life (QoL) in patients with head and neck cancer (HNC) during the early stages of radiotherapy (RT). According to findings, no later than two weeks of RT, pain intensity and depression negatively influenced QoL in patients with HNC. Early screening for pain and depression in a targeted preventive strategy could maintain QoL during the course of the RT for patients with HNC.