Robciuc A, et al. - Analysts ascertain the toxicity of pure glaucoma drugs (pGDs) (brimonidine tartrate, brinzolamide, latanoprost, timolol maleate, and pilocarpine hydrochloride) on ocular surface cells and aim to establish whether their toxicity is subsequent to cellular membrane destabilization. This study demonstrates that all studied pGDs reduce the viability of the corneal epithelial cells, but none of the tested compounds were able to destabilize cellular membranes. The pGDs appear to be internalized and can induce apoptosis through C/EBP homologous protein recruitment.