Nelson J, et al. - Herein, the researchers examined if sinonasal secretions were transferred to the lungs in patients with cystic fibrosis (CF)-related sinus disease and healthy individuals, especially in the recumbent position and during sleep. Evidence was yielded with regard to the aspiration of sinonasal secretions into the lungs of patients with CF and healthy adults in the recumbent position. Since both patients and controls aspirated secretions, it was deduced that aspiration alone did not account for the pathogenesis of lung disease in CF patients.