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Pubertal timing and adult fracture risk in men: A population-based cohort study

PLoS Medicine Dec 12, 2019

Vandenput L, et al. - Researchers examined fracture risk in adult men in relation to age at peak height velocity (PHV), an objective measure of pubertal timing. Participants were Swedish men (n = 31,971) who were born between January 1, 1945, and December 31, 1961, and for whom detailed growth data (height and weight) was obtained from centrally archived school healthcare records and the conscription register. These people were followed until December 31, 2016, in the BMI Epidemiology Study Gothenburg. They calculated age at PHV as per a modified infancy–childhood–puberty model, and obtained fracture information from the Swedish National Patient Register. Findings revealed increased adult fracture risk in men in relation to late pubertal timing. This implies that the recognition of men at greatest risk of fracture might be assisted by information on pubertal timing.
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