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Pubertal BMI change and adult-onset asthma in men: Population-based cohort study in Sweden

Clinical & Experimental Allergy Nov 22, 2019

Nwaru BI, et al. - In this study performed on Swedish men, researchers examined the link of childhood and young adult BMI, and pubertal BMI alteration with adult-onset asthma, allergic rhinitis, and concomitant asthma and rhinitis. Height and weight measures obtained from school health records (6.5-9.5 years) and during military conscription (17.5-22 years) for 37,652 men born 1945-1961, were included in the BMI Epidemiology Study in Gothenburg, Sweden. Increased risk of concomitant asthma and allergic rhinitis was observed in relation to high BMI (4th quartile vs the two median quartiles) at 8 years. They also noted an increased risk of asthma without concomitant allergic rhinitis as a main or auxiliary diagnosis in correlation with overweight and obesity at 20 years. A non-linear link was demonstrated by pubertal BMI change so that increased risk of asthma, as well as asthma without concomitant allergic rhinitis as the main diagnosis, was observed in relation to both low and high pubertal BMI alteration. Findings revealed that adult-onset asthma in men, especially asthma without concomitant allergic rhinitis, was predicted by both low and high pubertal BMI change. Monitoring of shifts in BMI during puberty is needed in order to ensure primary prevention of adult-onset asthma.
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