Mimic A, et al. - Researchers ascertained psychological factors that could contribute to individual responses to analgesics and surgical pain response and investigated patients who underwent a standardized surgical intervention (open nephrectomy). Epidural analgesia after open nephrectomy demonstrated a clear advantage for pain management only within the first 24 hours. Also, as in the first 72 postoperative hours, the psychological phenotype of patients changed distinctively, pain intensity was increasingly determined with psychological variables, even surpassing employed analgesic strategy as its main predictor.