Villeneuve S, et al. - Experts aspired to determine if sporadic parental estimated years to symptom onset calculation could aid in identifying information regarding amyloid-β (Aβ) levels in asymptomatic subjects with a parental history of Alzheimer's disease (AD) dementia. Based on the results, it was found that proximity to parental symptom onset could assist in determining Aβ biomarker changes in women or APOE4 carrier asymptomatic individuals with a parental history of sporadic AD.