Kuljanin M, et al. - Researchers undertook this study to evaluate the secretome of human bone marrow (BM)-derived multipotent stromal cells (MSCs) with documented islet regenerative paracrine function. They deliberated that regenerative multipotent stromal cells will secrete a unique combination of protein factors that augment islet regeneration. Remarkably, maintenance of active Wnt signalling within human MSCs promotes the secretion of matricellular and proangiogenic proteins that formulate a niche for islet regeneration.