Kasaian MT, et al. - Researchers carried out proteomics using Olink proximity extension analysis in order to identify signatures as determinants of asthma disease control. Controlled and poorly controlled asthmatics were included, along with an additional cohort of 9 subjects whose serum was collected within 48 hours of asthma exacerbation. Quantification of 181 separate protein analytes in serum and sputum was carried out using two separate pre-defined Proseek Multiplex panels (INF and CVDIII). Controlled and poorly controlled asthmatics were successfully distinguished by proteomic profiles in serum and sputum; these profiles remained maintained over time. An association between sputum neutrophil markers and loss of asthma control was supported.