Zhu J, Zhang G, Song Z, et al. - Given that a role of protein kinase C-δ (PKCδ) in renal tubular injury during cisplatin nephrotoxicity and albumin-related kidney injury has been reported earlier, so, researchers determined if PKCδ is implicated in ischemic or transplantation-associated kidney injury. For this purpose, they took rat kidney proximal tubule cells to incubate those in University of Wisconsin solution at 4°C for cold storage, returning them to normal culture medium at 37°C for rewarming. Both in vitro and in vivo models of cold-storage rewarming or transplantation showed PKCδ activation. Findings are suggestive of the role of PKCδ as a key mediator of mitochondrial damage as well as renal tubular injury in cold storage–associated transplantation. Also, the likely effectiveness of PKCδ was suggested as a treatment target for improving renal transplant results.