Tala JA, Polikoff LA, Pinto MG, et al. - Because there are no tests to recognize critically ill children at high risk of deep venous thrombosis (DVT), investigators sought to recognize proteins that were correlated with incident DVT in critically ill adolescents. They obtained plasma samples from critically ill adolescents within 24 hours following the initiation of cardiopulmonary support. The adolescents were followed with ultrasound to identify the development of DVT of the lower extremity and clinically for bleeding. They analyzed plasma from 59 critically ill adolescents, of whom 9 developed incident DVT. The DVT was associated with higher levels of thrombin-antithrombin complex and lower levels of factor XIII. Overall, it was identified that candidate protein biomarkers for incident DVT.