Protective effects of dietary intake of antioxidants and treatment-related toxicity in childhood leukemia: A report from the DALLT cohort
Journal of Clinical Oncology Jul 01, 2020
Ladas EJ, Blonquist TM, Puligandla M, et al. - This prospective clinical trial was performed to investigate if and how dietary intake of antioxidants could influence the rates of infections, mucositis, relapse, as well as disease-free survival during induction and postinduction phases of therapy in children and adolescents suffering from acute lymphoblastic leukemia (ALL). Overall 794 pediatric patients were enrolled. A prospective analysis of dietary intake was done using a food frequency questionnaire. Findings revealed decreased rates of infection or mucositis in correlation with dietary intake of antioxidants. At the same time, this dietary intervention was not associated with raised risk of relapse or decreased survival. So, it was concluded that dietary counseling on a well-balanced diet that incorporates an array of antioxidants from food sources alone may be beneficial for infections as well as mucositis during treatment of childhood ALL.
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