Josse G, et al. - Researchers herein over a long period of time evaluated the lentigines' pigmentation. They also assessed that whether over-pigmentation could be avoided by the use a day skin cream with SPF30. Findings demonstrated that the use of SPF30 day skin cream could help in avoiding over-pigmentation. They demonstrated that very fine re-registration of the reflectance confocal microscopy (RCM) images was possible and ensured a more robust analysis.