Madan R, et al. - As comedonecrosis in prostate cancer has always been Gleason pattern 5, researchers here evaluated how intraductal carcinoma (not graded) with comedonecrosis should be considered. They determined the immunohistochemistry for basal cells in 40 radical prostatectomy patients. Outcomes suggest that prostate cancer with comedonecrosis is often intraductal. Overwhelmingly high-stage of these tumors indicates a higher rate of positive lymph nodes with invasive comedonecrosis. Consideration to immunohistochemistry could be given when comedonecrosis may significantly change the tumor grade. Further study is required to clarify that excluding intraductal carcinoma from the grade is superior when associated with high-grade invasive cancer.